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Genome Biology volume 3, Article number: spotlight-20020403-01 (2002)
Group AStreptococcus(GAS) infection by serotype M18 strains causes acute rheumatic fever (ARF) and can lead to pediatric heart disease. In the April 2 Proceedings of the National Academy of Sciences, James Smoot and colleagues at the National Institute of Allergy and Infectious Diseases report the genome sequence of a GAS strain (MGAS8232) isolated from a patient with ARF (Proc Natl Acad Sci USA 2002, 99:4668-4673). They compared the 1.9 Mb genome with a closely related strain (the M1 serotype SF370 strain) and found 178 putative genes unique to MGAS8232. Several of these encode secreted proteins that may be important for host-GAS interactions. Microarray analysis of different serotype M18 strains revealed that much of the genetic variation was due to phage or phage-like sequence elements. Comparative GAS genomics should lead to greater understanding of ARF pathogenesis and potential therapeutic strategies.
Pathogenesis of group A streptococcal infections.
Proceedings of the National Academy of Sciences, [http://www.pnas.org]
National Institute of Allergy and Infectious Diseases , [http://www.niaid.nih.gov]
Complete genome sequence of an M1 strain of Streptococcus pyogenes.
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Weitzman, J.B. Strep genomics. Genome Biol 3, spotlight-20020403-01 (2002). https://doi.org/10.1186/gb-spotlight-20020403-01
- Heart Disease
- Genome Sequence
- Therapeutic Strategy
- Microarray Analysis
- Secrete Protein