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Genome Biology volume 3, Article number: spotlight-20020328-03 (2002)
Large families of RNA molecules of 21-22 nucleotides, called microRNAs, have been found in a number of species. In an Advanced Online Publication from Nature Genetics, Eric Lai from the University of California at Berkley, describes a family of microRNAs in Drosophila (18 March 2002, DOI:10.1038/ng865). He found that 11 DrosophilamicroRNAs are complementary to the K-box motif (cUGUGAUa), Brd box (AGCUUUA) and GY box (uGUCUUCC) motifs present in the 3' untranslated regions (UTRs) of several basic helix-loop-helix genes (bHLH). The microRNA may bind these sequences and mediate negative post-transcriptional regulation. The conservation of some microRNAs in man and worms will prompt work on defining a regulatory role for microRNA-3'UTR RNA duplexes.
Identification of novel genes coding for small expressed RNAs.
Nature Genetics, [http://www.nature.com/ng/]
University of California at Berkley , [http://www.berkeley.edu]
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Weitzman, J.B. MicroRNAs. Genome Biol 3, spotlight-20020328-03 (2002). https://doi.org/10.1186/gb-spotlight-20020328-03
- Untranslated Region
- Regulatory Role
- Large Family
- Online Publication