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Open Access

MicroRNAs

  • Jonathan B Weitzman
Genome Biology20023:spotlight-20020328-03

https://doi.org/10.1186/gb-spotlight-20020328-03

Published: 28 March 2002

Large families of RNA molecules of 21-22 nucleotides, called microRNAs, have been found in a number of species. In an Advanced Online Publication from Nature Genetics, Eric Lai from the University of California at Berkley, describes a family of microRNAs in Drosophila (18 March 2002, DOI:10.1038/ng865). He found that 11 DrosophilamicroRNAs are complementary to the K-box motif (cUGUGAUa), Brd box (AGCUUUA) and GY box (uGUCUUCC) motifs present in the 3' untranslated regions (UTRs) of several basic helix-loop-helix genes (bHLH). The microRNA may bind these sequences and mediate negative post-transcriptional regulation. The conservation of some microRNAs in man and worms will prompt work on defining a regulatory role for microRNA-3'UTR RNA duplexes.

References

  1. Identification of novel genes coding for small expressed RNAs.Google Scholar
  2. Nature Genetics, [http://www.nature.com/ng/]
  3. University of California at Berkley , [http://www.berkeley.edu]

Copyright

© BioMed Central Ltd 2002

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