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Monkey map

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Following the completed draft of the human genome sequence, there is renewed interest in the genetic differences between species and, particularly, in what makes us human. In the January 4 Science, Asao Fujiyama and colleagues at the RIKEN Genomic Sciences Center in Japan present a first-generation human-chimpanzee comparative genome map (Science 2002, 295:131-134). They used over 77,000 chimp bacterial artificial chromosomes (BAC) and aligned end-sequences with the human genomic sequence. The BAC clones covered almost half of the human genome. They calculated that the degree of identity with human sequences is about 98.77%. Closer analysis of chromosome 21 provided evidence for several human-specific loci. This map represents a step towards discovering what makes us different from our closest relatives, the apes.

References

  1. 1.

    Science, [http://www.sciencemag.org]

  2. 2.

    RIKEN Genomic Sciences Center , [http://www.gsc.riken.go.jp]

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Weitzman, J.B. Monkey map. Genome Biol 3, spotlight-20020104-01 (2002) doi:10.1186/gb-spotlight-20020104-01

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Keywords

  • Genome Sequence
  • Human Genome
  • Close Relative
  • Bacterial Artificial Chromosome
  • Genetic Difference