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Open Access

Cycling surprises

  • William Wells
Genome Biology20012:spotlight-20010104-03

https://doi.org/10.1186/gb-spotlight-20010104-03

Published: 04 January 2001

Keywords

Cell CycleClassification SystemHuman CellFunctional ClassificationHuman Gene

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare daughter cells for migration away from each other), and of extracellular matrix-associated genes in M (possibly to enhance the re-establishment of cell-cell contact and communication after mitosis).

References

  1. Expression monitoring by hybridization to high-density oligonucleotide arrays.Google Scholar
  2. A genome-wide transcriptional analysis of the mitotic cell cycle.Google Scholar
  3. Nature Genetics, [http://www.nature.com/ng/]
  4. Supplementary data to Nat Genet 2000, 27:48-54, [http://www.salk.edu/LABS/chipdata/]

Copyright

© BioMed Central Ltd 2001

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