Skip to main content
  • Research news
  • Published:

Cycling surprises

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare daughter cells for migration away from each other), and of extracellular matrix-associated genes in M (possibly to enhance the re-establishment of cell-cell contact and communication after mitosis).


  1. Expression monitoring by hybridization to high-density oligonucleotide arrays.

  2. A genome-wide transcriptional analysis of the mitotic cell cycle.

  3. Nature Genetics, []

  4. Supplementary data to Nat Genet 2000, 27:48-54, []

Download references


Rights and permissions

Reprints and permissions

About this article

Cite this article

Wells, W. Cycling surprises. Genome Biol 2, spotlight-20010104-03 (2001).

Download citation

  • Published:

  • DOI: