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Cycling surprises

Array analysis of dividing cells has been tackled for yeast, but in the January Nature Genetics Cho et al. present the first large-scale analysis in human cells (Nat Genet 2001, 27:48-54). They identify731 of 40,000 human genes and expressed sequence tags (ESTs) as being cell cycle regulated in primary fibroblasts, and use a functional classification system to identify coordinate regulation of pathways. Notable surprises include upregulation of motility-related genes in G2 (perhaps to prepare daughter cells for migration away from each other), and of extracellular matrix-associated genes in M (possibly to enhance the re-establishment of cell-cell contact and communication after mitosis).


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    Expression monitoring by hybridization to high-density oligonucleotide arrays.

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    A genome-wide transcriptional analysis of the mitotic cell cycle.

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    Nature Genetics, []

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    Supplementary data to Nat Genet 2000, 27:48-54, []

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Wells, W. Cycling surprises. Genome Biol 2, spotlight-20010104-03 (2001).

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  • Cell Cycle
  • Classification System
  • Human Cell
  • Functional Classification
  • Human Gene