Open Access

Malaria's dangerous neighborhood

  • William Wells
Genome Biology20001:spotlight-20001031-02

https://doi.org/10.1186/gb-spotlight-20001031-02

Published: 31 October 2000

The var genes of the malaria parasite Plasmodium falciparum encode the major variable parasite protein and are expressed in a mutually exclusive manner at the surface of an infected red blood cell. In the 26 October Nature, Freitas-Junior et al. report that Plasmodium uses nuclear architecture in a pathogen survival strategy (Nature 2000, 407:1018-1022). The sub-telomeric regions that contain the var genes are clustered together at the nuclear periphery, apparently allowing recombination at frequenciesmuch higher than those expected from homologous crossover events alone.

References

  1. Nature, [http://www.nature.com/nature/]
  2. A genetic map and recombination parameters of the human malaria parasite Plasmodium falciparum.Google Scholar

Copyright

© BioMed Central Ltd 2000

Advertisement