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Could selfish DNA create new proteins?

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Selfish DNA has been defined as DNA "with no phenotypic expression whose only 'function' is survival within genomes." In the 13 October Science, [] Ogata et al. find what appears to be selfish DNA lodged in the middle of 19 genes of Rickettsia conorii [], an intracellular bacterium of ticks (Science 2000, 290:347-350). The repeats are palindromes that encode a mildly hydrophobic α helix surrounded by two extended or coil regions. This appears to be a non-functional module that has been inserted at the surface of a collection of unrelated proteins. Although the inserts probably do not provide a specific function, genetic drift from the original sequence could allow the evolution of new protein sequences, domains and functions.


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    Selfish genes, the phenotype paradigm and genome evolution.

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    Science, []

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    Rickettsioses as paradigms of new or emerging infectious diseases.

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  • Protein Sequence
  • Specific Function
  • Genetic Drift
  • Phenotypic Expression
  • Original Sequence