Open Access

Interfering nonsense

  • William Wells
Genome Biology20001:spotlight-20000918-02

https://doi.org/10.1186/gb-spotlight-20000918-02

Published: 18 September 2000

In RNA interference (RNAi), introduced double-stranded RNA (dsRNA) triggers gene-specific silencing by inducing mRNA degradation. Domeier et al. report in the 15 September Science that some of the worm SMG proteins, which are required for nonsense-mediated mRNA decay, are also required for maintenance of RNAi (Science 2000, 289:1928-1930). RNAi is initiated in the smg mutants as normal, but the animals subsequently recover. SMG proteins may be involved in an amplification step of RNAi. The proteins' possible cleavage or dsRNA-unwinding activities could provide templates for an RNA-directed RNA polymerase.

References

  1. RNA-triggered gene silencing.Google Scholar
  2. Science magazine, [http://www.sciencemag.org/]
  3. smg-7 is required for mRNA surveillance in Caenorhabditis elegans.Google Scholar
  4. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans.Google Scholar

Copyright

© BioMed Central Ltd 2000

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