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No iron in Lyme

Iron sequestration is one way that human cells limit bacterial growth. In the 2 June issue of Science, Posey and Gherardini show that the Lyme disease pathogen, Borrelia burgdorferi, has responded by eliminating most genes that encode iron-requiring proteins, and substituting manganese for iron in the few metalloproteins that are left (Science 2000, 288:1651-1653). This is possible because the bacterium is an obligate parasite that lacks the enzymes for most biosynthetic pathways. As a result the bacterium grows happily with fewer than 10 atoms of iron present per cell.

References

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    Iron uptake mechanisms of pathogenic bacteria.

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    Science Magazine, [http://www.sciencemag.org/]

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Wells, W. No iron in Lyme. Genome Biol 1, spotlight-20000609-02 (2000). https://doi.org/10.1186/gb-spotlight-20000609-02

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Keywords

  • Iron
  • Manganese
  • Human Cell
  • Bacterial Growth
  • Biosynthetic Pathway