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Table 4 Comparison of Ich and Tetrahymena membrane transporters according to TC class, superfamily and substrate type

From: Comparative genomics of the pathogenic ciliate Ichthyophthirius multifiliis, its free-living relatives and a host species provide insights into adoption of a parasitic lifestyle and prospects for disease control

  Number of transporters in Ich (percentage of total transporters) Number of transporters in Tetrahymena(percentage of total transporters)
TC class   
   1. Channels 155 (32) 418 (38)
   2. Secondary carriers 191 (40) 386 (36)
   3. Primary active transporters 131 (27) 269 (25)
   9. Poorly characterized transporters 6 (1) 13 (1)
   Total 483 1086
TC superfamily   
   VIC 116 (24) 396 (36)
   APC 7 (1) 64 (6)
   MFS 75 (16) 146 (13)
   MC 38 (8) 43 (4)
   CPA 16 (3) 20 (2)
   ABC 40 (8) 159 (15)
   P-ATPase 65 (13) 91 (8)
Substrate type   
   Inorganic molecules 249 (51) 500 (53)
   Carbon sources 54 (11) 77 (8)
   Drugs, toxins, macromolecules 77 (16) 155 (17)
   Vitamins, co-factors 15 (3) 23 (2)
   Nucleotide bases and derivatives 21 (4) 26 (3)
   Amino acids and derivatives 34 (7) 49 (5)
   Unknown 38 (8) 110 (12)
  1. MFS, major facilitator superfamily; VIC, voltage-gated ion channel; MC, mitochondrial carrier; CPA, cation:proton antiporter.