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Table 4 Over-represented Gene Ontology terms in REB, MREB and PS genes in avian lineages

From: Molecular evolution of genes in avian genomes

  Ancestral bird lineage Chicken lineage Zebra finch lineage
Gene Ontologya N1b N2c Excess P N1b N2c Excess P N1b N2c Excess P
Rapidly evolving in birds (REB)             
   Biological adhesion (B 2) 17 136 2.67 0.013         
   Cell adhesion (B 3) 17 135 2.69 0.013         
   Cytokine secretion (B 7) 4 5 17.06 0.013         
   Telomere organization (B 5)      5 5 7.81 0.024     
   Telomere maintenance (B 6)      5 5 7.81 0.024     
   Sterol transport (B 5)      6 7 6.69 0.024     
   Cholesterol transport (B 6)      6 7 6.69 0.024     
More rapidly evolving in birds (MREB) than in other amniotes             
   Biological adhesion (B 2) 12 136 5.82 0.0002         
   Cell adhesion (B 3) 12 135 5.86 0.0002         
   Blood vessel development/maturation (B5) 2 2 65.94 0.061         
   Synapse organization and biogenesis (B 5) 3 12 16.49 0.088         
   Integrin-mediated signaling pathway (B 6) 3 11 17.98 0.088         
   Proteinaceous extracellular matrix (C 3)             
   Cytoskeletal part (C 5)          37 124 1.92 0.040
   Microtubule cytoskeleton (C 7)          27 83 2.09 0.040
Positively selected (PS) in birds             
   Biological adhesion (B 2) 16 148 3.27 0.016         
   Cell adhesion (B 3) 16 147 3.29 0.016         
   Cell-cell adhesion (B 4) 9 57 4.78 0.035         
   Homophilic cell adhesion (B 5) 5 16 9.45 0.035         
   Calcium ion binding (M 5) 14 154 2.74 0.035         
   Anion transmembrane transport activity (M 6)      16 48 3.00 0.006     
  1. Terms with a false discovery rate (FDR) of adjusted P < 0.1 are shown. Excess is the fold enrichment for significant Gene Ontology terms. aB is biological process, M is molecular function and C is cellular component. The numbers indicate hierarchical level. bNumber of genes in test sample (REB, MREB and PS, respectively). cNumber of genes in reference sample (1:1 orthologs found in the respective lineage).