Figure 1

A diagram of the known components of metastasis-controlling signal transduction cascades that involve Dicer. While the suppressive effects of miR-31, miR-126, miR-206, and miR-335 on metastasis have been directly documented in vivo [8, 9], the roles of miR-130 and miR-200 in metastasis are implied by in vitro studies [3, 7], but have yet to be analyzed directly in vivo.