Schematic domain structure of WOX family proteins. Domains were defined using manual annotation of a multiple sequence alignment and subsequent generation and matching of hidden Markov models using HMMER . The homeodomain (HD) (red) is the most prominent and defining feature of the family. The WUS-box motif (green) was defined in a strict sense, as T-L- [DEQP]-L-F-P- [GITVL]-[GSKNTCV], consensus TLELFPLH. The ERF-associated amphiphilic repression (EAR) motif (blue) was also defined in a strict sense, as L- [ED]-L- [RST]-L, in which form it can be detected at the carboxy-terminal end of the WUS, WOX5 and WOX7 proteins.