Evolution of protein complexes by duplication of homomeric interactions

Table 2 Evolutionary origin of dimers of paralogues

	P(HD)	P(PD)	P(HD\|PD)	P(PD\|HD)
Yeast	0.034 ± 0.006	0.134 ± 0.011	0.043 ± 0.006	0.17 ± 0.012
Yeast-large	0.027 ± 0.001	0.062 ± 0.002	0.203 ± 0.003	0.466 ± 0.004
Fly	0.047 ± 0.004	0.091 ± 0.006	0.082 ± 0.006	0.257 ± 0.008
Worm	0.031 ± 0.003	0.033 ± 0.003	0.355 ± 0.008	0.379 ± 0.008

Dimers of paralogues are frequently also homodimers. HD, homodimer; PD, dimer of paralogues. P(HD|PD) should be read as the conditional probability of a polypeptide forming a homodimer given that it also participates in forming a dimer of paralogues. The standard deviations for each probability are calculated from √(p(1 - p)/n) where p is the estimated probability and n the number of observations. The enrichment observed with the conditional probabilities is significant for all interaction datasets except the small yeast network.

ISSN: 1474-760X