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Table 2 Evolutionary origin of dimers of paralogues

From: Evolution of protein complexes by duplication of homomeric interactions

  P(HD) P(PD) P(HD|PD) P(PD|HD)
Yeast 0.034 ± 0.006 0.134 ± 0.011 0.043 ± 0.006 0.17 ± 0.012
Yeast-large 0.027 ± 0.001 0.062 ± 0.002 0.203 ± 0.003 0.466 ± 0.004
Fly 0.047 ± 0.004 0.091 ± 0.006 0.082 ± 0.006 0.257 ± 0.008
Worm 0.031 ± 0.003 0.033 ± 0.003 0.355 ± 0.008 0.379 ± 0.008
  1. Dimers of paralogues are frequently also homodimers. HD, homodimer; PD, dimer of paralogues. P(HD|PD) should be read as the conditional probability of a polypeptide forming a homodimer given that it also participates in forming a dimer of paralogues. The standard deviations for each probability are calculated from √(p(1 - p)/n) where p is the estimated probability and n the number of observations. The enrichment observed with the conditional probabilities is significant for all interaction datasets except the small yeast network.