Finding disease candidate genes by liquid association

Table 1 Genetic association results for SNPs located in the SLC1A3 gene in Finnish multiple sclerosis families

All families (n=69) and HLA stratified (n=38)
SNP ID	TDT, P value	TDT, P value	MAF (CEPH)	MAF (Finnish)
rs2562582	0.005	0.0002	0.175	0.169
rs10941306	0.344	0.5	0.317	0.378
rs1366632	0.49	0.4898	0.458	0.459
rs1544795	0.477	0.5	0.467	0.437
rs1549627	0.5	0.4765	0.44	0.45

MAF (CEPH) is the minor allele frequency, as calculated from genotyping 30 trios belonging to Centre d'Etude du Polymorphisme Humain (CEPH) panel by HapMap project. MAF (Finnish) is the minor allele frequency calculated from genotyping the Finnish families used in this study. The transmission disequilibrium tests (TDTs) were calculated using ANALYZE software package [48]. In all, 69 families are included in this analysis, of which 38 are HLA stratified (multiple sclerosis families in which the affected individual had one or two HLA single nucleotide polymorphism [SNP] 2239802 risk alleles).

ISSN: 1474-760X