Skip to main content

Table 3 Human protein-interaction assay false-positive rates: human datasets

From: How complete are current yeast and human protein-interaction networks?

Dataset Number of unique interactions Derived false-positive rates* (%) Published false-positive rates (%) Average false-positive rates (%)
Lehner and Fraser [40] 58,700 (9,396 core) 96, 94, 93 (86, 81, 69 core) - 94 (79 core)
Rhodes et al. [23] 38,379 87, 86, 83 - 85
Stelzl et al. [15] 3,150 (902 core) 98, 98 (94,95 core) 70 [45] 98 (86 core)
Rual et al. [14] 2,611 87, 93 8-66 [14], 54 [45] 58
Overall 100,242    90
  1. *This interaction assay false-positive rate is derived using the method of D'haeseleer and Church [32] and a reference set of 20,296 unique interactions from HPRD [54], BIND [55], Reactome [56], and Ramani et al. [49]. Multiple values derive from different choices of comparison sets. A range of six values (mean 48%) estimated from Table 1 of Rual et al. [14] by fitting the interaction set CCSB-HI1 as a linear combination of true positive (LCI-core) and false positive (all possible) interactions.