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Table 5 lin-35 and lin-15B enhance somatic transgene silencing by an RNAi dependent mechanism

From: Loss of LIN-35, the Caenorhabditis elegansortholog of the tumor suppressor p105Rb, results in enhanced RNA interference

RNAi*

GFP expression

% Complete expression

 

Complete†

Partial‡

 

control

27

2

93%

dcr-1; control

15

0

100%

rde-4; control

19

0

100%

lin-35; control

1

11

8%

lin-35; dcr-1

11

18

38%

lin-35; rde-4

14

17

45%

lin-15B; control

2

14

13%

lin-15B; dcr-1

30

2

94%

lin-15B; rde-4

25

5

83%

  1. *RNAi experiments were performed as described in Materials and methods. †Number of worms with GFP expression in all hypodermal seam cells. ‡Number of worms with GFP expression only in their anterior and/or posterior seam cells, but not in the midbody seam cells.
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Genome Biology

ISSN: 1474-760X

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