New clues to the puzzle of mammalian sex determination

Table 1 Phenotypes of WT1-isoform-specific knockout mice

	Sex	Gonadal phenotype	Sry (11.5 dpc)	Sox9 (12.5 dpc)	Dax1 (11.5 dpc)	Amh (12.5 dpc)
Wild-type mice
	XY	Testis	+	+++	+	++++
	XX	Ovary	-	-	+	-
Frasier mice (no WT1^+KTS)
	XY	Ovary	25%	-	Similar or slight increase	ND
	XX	Ovary	-	-	relative to wild type^*	ND
KTS mice (no WT1^-KTS)
	XY	Small, undifferentiated	ND	- (+ in rare cells)	Lower than	- (+ in rare cells)
	XX	gonads	-	-	wild type	-

Based on data from Hammes et al. [3]. ND, not determined; dpc, days post coitum. ^* Seven arbitrary units in XY Frasier compared to five in XY wild type, with unknown standard errors, as measured by quantitative PCR.

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