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  • Invited speaker presentation
  • Open Access

The Joint Center for Structural Genomics: exploration of the human gut microbiome

  • 1
Genome Biology201112 (Suppl 1) :I18

  • Published:


  • Metabolic Network
  • Structural Genomic
  • Medical Research Institute
  • Bacterial Phyla
  • Uncharacterized Protein

For more than a decade, the Joint Center for Structural Genomics (JCSG) [1] has been at the forefront of developing tools and methodologies that allow the application of high-throughput structural biology to a broad range of biological and biomedical investigations. In the previous phases of the National Institutes of Health’s Protein Structure Initiative (PSI; 2000 to 2010) [2], we explored structural coverage of uncharted regions of the protein universe [3], as well as a single organism, allowing complete structural reconstruction of the metabolic network of Thermotoga maritima[4]. In the current phase (PSI: Biology; 2010 to 2015), the JCSG is leveraging its high-throughput platform to explore the structural basis for host-microbe interactions in the human microbiome. The emerging field of metagenomics has been particularly enlightening: the human gut microbiome sequencing projects have already uncovered fascinating new families and expansions of known families for adaptation to this environment. The gut microbiota is dominated by poorly characterized bacterial phyla, which contain an unusually high number of uncharacterized proteins that are largely unstudied. Their influence upon human development, physiology, immunity and nutrition is only starting to surface and is thus an exciting new frontier for structural genomics, where we can structurally investigate the contributions of these microorganisms to human health and disease. The JCSG is located at The Scripps Research Institute, the Genomics Institute of the Novartis Research Foundation, University of California at San Diego, the Sanford-Burnham Medical Research Institute and SSRL/Stanford University.

Authors’ Affiliations

The Scripps Research Institute, 10550 North Torrey Pines Road, La Jolla, CA 92037, USA


  1. The Joint Center for Structural Genomics[]
  2. The Protein Structure Initiative[]
  3. Jaroszewski L, Li Z, Krishna SS, Bakolitsa C, Wooley J, Deacon AM, Wilson IA, Godzik A: Exploration of uncharted regions of the protein universe.PLoS Biol 2009, 7:e1000205.PubMedPubMed CentralView ArticleGoogle Scholar
  4. Zhang Y, Thiele I, Weekes D, Li Z, Jaroszewski L, Ginalski K, Deacon AM, Wooley J, Lesley SA, Wilson IA, Palsson B, Osterman A, Godzik A: Three-dimensional structural view of the central metabolic network ofThermotoga maritima.Science 2009, 325:1544–1549.PubMedPubMed CentralView ArticleGoogle Scholar


© BioMed Central Ltd 2011