Fig. 2

Integrative analysis of metabolome, proteome, and transcriptome data of pear flesh. a Clustering analysis of proteome data shows the three reliable replicates of each sample at any stage. Z-score standardized value of each protein across all 11 stages (from S1 to S11) were used for clustering analysis. b Clustering analysis of transcriptome data shows the three reliable replicates of each sample at any stage. Z-score standardized value of each gene across all 11 stages was used for clustering analysis. The color bar indicates the increasing expression levels of both protein and gene from blue to red. c Peonidin-3-galactoside biosynthesis pathway. d Sugar biosynthesis and metabolic process. e Abscisic acid biosynthesis pathway. The pathway genes with the background of red color were positively correlated to the target metabolites (highlighted by blue box). f The metabolic regulatory network for each metabolite cluster. I → VIII indicate the different clusters