Fig. 5

Endogenous Apobec enzymes are not responsible for the observed RNA editing. A Average expression levels of the different endogenous Apobec and Adar family members in liver samples obtained from RNA seq data (transcripts per million (TPMs); each dot represents data from one animal n = 4 controls and 9 A3B livers). B Average expression levels of Apobec1 cofactors obtained from the RNA seq data and shown as transcripts per million (TPMs); each dot represents data from one animal (n = 4 controls and 9 A3B livers). C Frequency of C-to-U mRNA editing in well-known Apobec1 editing sites measured by quantification of RNA seq data from controls and A3B livers. Each dot represents data from one animal (n = 4 controls and 9 A3B livers). D) Schematic of the breeding strategy to obtain A3B/Apobec1^−/− mice. E Lollipop plots indicating the percentage of mice showing C-to-U editing after experimental validation by RT-PCR in selected targets in A3B/Apobec1.^−/− mice (n = 6 liver tissues)