Fig. 2
From: Acute expression of human APOBEC3B in mice results in RNA editing and lethality
A3B overexpression causes early lethality. A Survival of TetO-A3B/CAGs-rtTA3 mice after doxycycline administration (controls n = 9; A3B n = 26; P < 0.0001 by Log-rank (Mantel-Cox) test). B H&E-stained sections of livers from control and A3B mice (insets: macroscopic images). Asterisk point microvesicular steatosis, arrowhead point lymphocytes and arrows to apoptotic cells. C Immunohistochemistry against C-Caspase3 and γH2AX in liver sections from control and A3B mice and corresponding quantification (n = 6). D H&E-stained sections of the pancreas from control and A3B mice. Arrowheads point to lymphoplasmacellular infiltration and arrows to apoptotic cells. E Immunohistochemistry against C-Caspase3 and γH2AX in paraffin sections from control and A3B pancreas and the corresponding quantification (n = 6). Data in panels C and E were analyzed by unpaired t-test **p < 0.01, ***p < 0.001, ****p < 0.0001. Data is represented as mean ± SD shown by dots, where each dot represents a mouse, and error bars, respectively. Scale bars: 100 μm. Scale bars upper panels B and D: 10 μm