Fig. 1

Determining the specific contribution of tumor-derived mtDNA in the circulation using an animal model. A Schematic of the workflow used to generate WGS data on n = 13 xenograft mouse models, created with BioRender.com. B The number of human derived (tumor-related) mtDNA reads and mouse derived (normal) mtDNA reads. Samples are sorted by increasing Peritoneal Cancer Index indicative of increasing tumor volume. C cfDNA fragment size density for human derived (tumor) reads and mouse derived (normal) reads