Fig. 9

Structure in human hematopoietic system data [104] (n = 2034 cells) inferred from the topic model with K = 10 topics (A) and HOMER motif enrichment analysis [105] applied to the results of the GoM DE analysis (B). In the Structure plot, the cells are grouped by FACS, as well as an unknown population from human bone marrow [104]. B shows HOMER enrichment results for selected motifs (for the full results, see Additional file 7: Table S8). Acronyms used: common lymphoid progenitor (CLP); common myeloid progenitor (CMP); granulocyte-macrophage progenitor (GMP); hematopoietic stem cell (HSC); lymphoid-primed multipotent progenitor (LMPP); megakaryocytic-erythroid progenitor (MEP); multi-potent progenitor (MPP); plasmacytoid dendritic cells (pDC)