Fig. 3

GoM DE analysis of the PBMC data using the topic model shown in Fig. 1. The volcano plots show posterior mean estimates of the l.e. LFC vs. posterior z-scores for 17,055 genes. The posterior z-score is defined as the posterior mean l.e. LFC divided by the posterior standard error. Genes are colored according to the local false sign rate (lfsr) [82]. A few genes with extreme posterior z-scores are shown with smaller posterior z-scores so that they fit within the y-axis range. See also the detailed GoM DE results (Additional file 2: Table S1), detailed GSEA results (Additional file 3: Table S3, S4), and the interactive volcano plots (Additional file 4)