Fig. 2

Toy example illustrating the least extreme LFC. Gene 1 has high expression in topic 1 and low expression in the other topics; \(p_{11} = \text {0.01}\), \(p_{1k} = \text {0.0001}\), k = 2, ..., 10. Gene 2 has high expression in topics 1 and 2 and low expression in the other topics; \(p_{21} = p_{22} = \text {0.01}\), \(p_{2k} = \text {0.0001}\), k = 3, ..., 10