Fig. 4

The H3K36me2 mark is inversely associated with PMDs in a cell-type-specific manner. A Aggregation plots of H3K36me2 ChIP-seq levels in esophageal cancer cell lines across four different PMD categories: shared PMDs, EAC-specific PMDs, ESCC-specific PMDs, shared HMDs. B Representative genomic loci showing H3K36me2 signal from ChIP-seq, and subtype-specific PMDs from WGBS data. CGI regions were masked using the annotation from Irizarry et al. [39]. C Aggregation plots of H3K36me2 ChIP-seq levels in HNSCC cell lines across four different PMD categories. H3K36me2 ChIP-seq datasets were obtained from GSE149670. H3K36me2 signals in A, C were normalized by the CPM ratio of IP over Input in 5-kb windows