Fig. 4From: Single-cell transcriptomics reveals multiple chemoresistant properties in leukemic stem and progenitor cells in pediatric AMLDynamic cellular and transcriptomic changes in leukemic cells after chemotherapy in P116, P105, and P115. a,c UMAP plots of leukemic cells from pre- and post-therapy samples for each patient, with cells color-coded by sample origin (a) and cell type (c). b Bar plot showing the number of leukemic cells in samples described in a. d Bar plot depicting the distribution of cell types in samples described in c. e Violin plots of normalized single-cell expression scores for LSC and OXPHOS signatures in HSC-like and LMPP-like cells from patients P116 and P105, with black dots representing average signature expression. PÂ values were calculated using the Wilcoxon signed-rank test. f Heatmap visualization of Metascape pathways enriched by upregulated genes in each cell population from post-therapy samples compared to pre-therapy samples. g Violin plots showing the expression of genes related to heme metabolism signaling pathways and response to reactive oxygen species in pre- and post-therapy cell populationsBack to article page