Fig. 5

Metabolic modules involving central carbon metabolism or nucleotide metabolism represented in the LBCA core genome. a Distribution of KEGG modules with at least one related orthogroup present in the LBCA core genome for varying gain/loss penalty thresholds (g). Module categories at the g = 1.0 threshold are shown, with visualized modules boxed. b Individual reactions in the LBCA core genome related to modules involving central carbon metabolism or nucleotide metabolism. Each reaction is labeled with the corresponding KEGG orthogroup(s) and gene name(s) and is colored by the minimum penalty ratio at which the corresponding orthogroup is present in the LBCA core (or maximum of ratios if multiple orthogroups are required). Missing reactions are colored white. Dashed gray arrows connect identical metabolites. For the starred reaction corresponding to K00609 (pyrB), the regulatory subunit K00610 (pyrI) is missing from the LBCA core genome but is not required for catalytic activity. For the double-starred reaction corresponding to K01057 (pgl), the closest COG orthogroup COG0363 represents sequences from both pgl and nagB