Fig. 5
From: Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Mutational signatures in bovine UC. a Signature extraction identified 2 novel single base substitution (SBS) signatures, designated Signatures BF-A and BF-B. The SBS mutational spectra are comprised of 96 substitution types, which are derived from six possible SBS mutations, each with 4 possible bases directly 5′ and 3′. The observed and reconstructed SBS mutation spectra of the samples with the lowest and highest mutation rates, BTAUD0029a (b) and BTAU0055a (c), respectively, are shown. d The absolute (upper panel) and relative (lower panel) proportion of mutations attributed to Signatures BF-A and BF-B in bovine UC samples. e The indel mutation spectrum of BTAUD0055a. f The doublet substitution spectrum in BTAUD0055a