Fig. 3

Comparative mutational landscape of human, canine, and feline urinary bladder UC. a The proportion of human MIBC cases [22] (n = 412) with somatic mutations in COSMIC Cancer Gene Census genes that have a one-to-one orthologous relationship with both a canine and a feline gene. Shown are mutations present in 4 or more canine or feline samples, which are prefixed with DD and CATD, respectively. Also shown are canine samples with MDM2 amplification, which is shown in the same row as TP53 mutations, to enable visual comparison with feline and human TP53 mutations. CDKN2A has not been included, as, although the feline cohort had 4 samples with CDKN2A mutations, Ensembl does not classify the human and feline genes as orthologs, and, in canines, human CDKN2B is designated an ortholog of canine CDKN2A. b Circos plot displaying genomic regions with recurrent somatic copy number alterations in human, feline, and canine UC. Chromosomes are represented by the outer track. Data for human chromosome X was not available. The histogram (inner track) shows the frequencies of copy number gains (purple, blue, and green) and losses (orange, red, and yellow) in human, canine, and feline, respectively. Links between chromosomes show syntenic regions within recurrently amplified/deleted chromosomes (feline and canine) or chromosome arms (human). Red links represent deletions and purple links represent amplifications. Genes shown in orange and purple text are in syntenic regions in chromosomes or chromosome arms that were recurrently deleted or amplified, respectively, in all 3 species. Genes in red and blue text are genes that were focally amplified or deleted in 2 or more species. ARHGEF10 is the only gene focally deleted in all 3 species. Shown in black text are other genes of interest