Fig. 2

Somatic mutational landscape of feline urinary bladder UC. a Somatic mutations in genes mutated in three or more samples. Asterisk indicates significantly mutated gene (SMG). A summary of feline cases analyzed in this study is provided in Additional File 1: Table S1b and a list of all variants is provided in Additional File 4: Table S3. b Single base pair (SBS) mutational spectrum for sample CATD0037a (upper panel). The activities of mutational signatures SBS1, SBS6, SBS20, and SBS21 are shown in the reconstructed mutational spectrum (lower panel). c Indel mutational spectrum for sample CATD0037a, showing a prevalence of single base pair deletions in homopolymer regions. d Penetrance plot showing somatic copy number gains and losses 5 Mb or larger in 1-Mb windows along each chromosome. Only samples with sufficient quality, based on manual inspection of Sequenza plots, are represented (n = 21; see ‘‘Methods’’)