Fig. 1
From: Cross-species oncogenomics offers insight into human muscle-invasive bladder cancer
Somatic mutational landscape of canine urinary bladder UC. a Somatic mutations in genes mutated in five or more samples. Asterisk indicates significantly mutated gene (SMG); GPRASP1 is also a SMG but is not shown, as it is mutated in 2 samples. A summary of the canine cases analyzed in this study is provided in Additional File 1: Table S1a and a full list of variants is provided in Additional File 3: Table S2. b Single base substitution (SBS) observed mutational spectra and reconstructed spectra for samples DD0194a and DD0355a. Mutational signatures SBS1 and SBS6 were found in both samples as well as SBS21 in sample DD0194a. The reconstructed mutational spectra based on these signatures have cosine similarity > 0.93 when compared to the observed spectra