Fig. 6
From: Cross-protein transfer learning substantially improves disease variant prediction
Cross-gene imputation. EVE scores are not available for the vast majority of human proteins. To scale our method to the whole human proteome, we imputed EVE scores and other features that depend on a large MSA in genes where they are not available. We assessed the quality of our imputation on genes where EVE scores are available, to measure how well we do compared to using the true values. A, B CPT-1 with imputed EVE still outperforms ESM-1v and the true EVE scores. C, D Imputed EVE scores improve performance of CPT-1 compared to removing them entirely, but there is still a gap to using the true EVE scores