Fig. 5From: Cross-protein transfer learning substantially improves disease variant predictionInsights from AlphaFold structures. A Specificity of CPT-1 in the clinically relevant high-sensitivity regime on ClinVar missense variants. Structural features slightly improve CPT-1 performance even though ProteinMPNN alone has poor performance. B Pathogenic ClinVar variants are more likely to have many contacts in the AlphaFold2 structure for the protein compared to benign variantsBack to article page