Fig. 5
From: Predicting the impact of sequence motifs on gene regulation using single-cell data
Motif cluster impact for the Tabula Muris dataset. a UMAP plots of 17,270 mouse promoters based on motif scores after the exponential linear unit and max pooling. Subplots show the summed motif scores (after the exponential linear unit and max pooling) for selected motif clusters in each promoter. b Spearman correlations between the expression of GO terms and aggregate motif influences in pools. Randomly selected enriched GO terms are shown for each cluster. c Spearman correlation between motif influence and expression levels of TFs binding to the motif in question. TFs with p-value ≥ 0.05 (after Benjamini-Hochberg correction) are in gray, the significant ones are colored by expression level, and selected TFs with the highest correlations for each cluster are named. d Correlations between aggregate motif family influence scores in pools and expression for selected TFs. The Spearman correlation is reported for each panel