Fig. 3
From: Predicting the impact of sequence motifs on gene regulation using single-cell data
Motif cluster impact for the human kidney dataset. a UMAP plots of 18,150 promoters based on motif occurrences after the ELU and max-pool operations. Subplots show the summed max-pooled motif scores after the ELU and max-pool operations (promoter activation) for selected motif clusters in each promoter. b Spearman correlation between motif influence scores and expression levels of TFs binding to the motif in question. TFs with p-value ≥ 0.05 (after Benjamini-Hochberg correction) are in gray, the significant ones are colored by expression level, and selected top TFs for each cluster are named. c Correlation between motif influence and expression of selected TFs across pools. The Spearman correlation is reported for each panel