Fig. 3

Allele-specific expression in tetraploid hybrid cells partitions differential expression into cis and trans components. A UMAP of hybrid cells after projection onto the space of Fig. 1B. B DE gene effect sizes in the hybrid vs. the effect sizes across humans and chimpanzees (for genes DE at p < 0.001). C Boxplot of estimated cis proportion in the top 1000 tests with the lowest estimate of standard error versus all other genes. D Empirical cumulative distributions of effect size (log2 fold-change from DREAM) for tests with high cis proportion (> 0.75), low cis proportion (< 0.25), or neither. E Boxplot of distribution of cis proportion for genes DE in increasingly large sets of cell types at posterior probability > 95%. F Boxplot of cis proportion for genes DE in more than 80% of tested cell types (at posterior probability > 95%) or all other genes