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Fig. 4 | Genome Biology

Fig. 4

From: L-GIREMI uncovers RNA editing sites in long-read RNA-seq

Fig. 4

Allele-specific editing reflected in the GM12878 long-read RNA-seq data. a Mutual information of known editing sites (REDIportal). Six sites with high mutual information were randomly chosen for experimental testing (arrows). b Summary of experimental validation results. Four out of 6 sites were confirmed as RNA editing sites. c–f Sanger sequencing traces for 4 confirmed editing sites. d IGV plot for an example allele-specific editing event: between the RNA editing site chr1:9102175 (red rectangle) and three heterozygous SNPs (blue rectangle). Note that the gene is on the − strand

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