Fig. 6
From: Genetic impacts on DNA methylation help elucidate regulatory genomic processes
Association between IBD and DNA methylation at site cg19297788. a Locus association plot. The grey dots represent the P-values of the SNPs from the IBD GWAS [56], the violet diamond the P-value of the SMR test, and the violet crosses the P-values of the meQTLs of cg19297788. b Effect sizes of IBD GWAS SNPs vs. effect sizes of meQTLs of cg19297788, for SNPs used in the HEIDI test. The slope of the dashed line represents the \(\beta _{\textrm{SMR}}\) estimate at the co-localised SNP. Error bars represent standard errors of estimated SNP effects. SNPs in LD with the top co-localised meQTL are expected to have a consistent effect under the causality/pleiotropy scenario