Fig. 3

For a given threshold x, safety coverage of the sequences whose stable structure retention is at least x (on the left), and the proportion of the sequences whose stable structure retention is at least x (on the right). The results are split into different identity ranges. a All 396k sequences are included. b Restricted to sequences whose safety coverage is at most 80%. The dark red curves, which cover sequences of all identities, show in a that around 20% of the sequences (right plot) have a stable structure retention of 100% and only 15% of safety coverage (left plot), while the purple curves, which cover sequences from the identity range 40–70%, show in b that 10% out of the sequences with at most 80% safety coverage inside this identity range (right plot) have a stable structure retention of 100% and only a safety coverage of around 5% (left plot)