Fig. 6
From: Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissues
Genomic locations of NMD-QTLs. a The coefficient estimations for \({\widehat{w}}_{1}\). b The coefficient estimations for \({\widehat{w}}_{2}\). \({\widehat{w}}_{1}\) and \({\widehat{w}}_{2}\) are for the model \({N}_{i,g}={w}_{0}+{w}_{1}{N}_{o,g}+{w}_{2}lo{g}_{2}\left({l}_{g}\right)\), where Ni,g is the number of NMD-QTLs (or eQTLs) inside a gene, No,g is the number of NMD-QTLs (or eQTLs) outside of any gene, and \({l}_{g}\) is the gene length. c The \({\widehat{w}}_{1}\) estimation for each tissue. Error bars: 95% confidence intervals. The \({\widehat{w}}_{1}\) estimations for NMD-QTLs are consistently larger than those for eQTLs, meaning that NMD-QTLs prefer locating inside a gene body. d The proportion of genic variants that are located on exons. The exonic proportions are significantly higher for NMD-QTLs, compared to eQTLs discovered for the same genes. e The scatter plots of the exonic proportions. The size of the symbol is proportional to the sample size for a specific tissue