Fig. 1
From: Mapping genetic variants for nonsense-mediated mRNA decay regulation across human tissues
Modeling of NMD-QTLs. a Identification of NMD-QTLs across human tissues based on the GTEx data. b Parameterization of the expression of NMD genes. t represents the total amount of transcribed transcripts, α represents the percentage of transcribed transcripts targeted by NMD, and θ represents the percentage of NMD-targeted transcripts that remained after degradation. The parameters can be different for different alleles of a genetic variant. c Allelic effect sizes of a pNMD-QTL, dNMD-QTL, or eQTL for NMD-targeted transcripts and non-NMD transcripts