Fig. 2
From: An Atlas of Variant Effects to understand the genome at nucleotide resolution
A (top panel) MAVEs can measure a wide variety of protein and regulatory DNA functions, and they produce comprehensive variant effect maps representing the effects of nearly all possible nucleotide or amino acid variants in the scanned functional element. A variant effect map is shown for a small region of a protein-coding gene; each column in the map is a position in a gene and each row is an amino acid substitution. Tiles are coloured based on the measured effect of the variant. B (bottom panel) MAVEs have been applied to hundreds of functional elements and, collectively, ~ 11 million variant effect measurements have been made with MAVEs. Data available at 10.5281/zenodo.7662580