Fig. 6
From: RAD21 is the core subunit of the cohesin complex involved in directing genome organization
A model illustrating the role of RAD21 as a core subunit of cohesin to extrude DNA and facilitate formation of vermicelli structure. Compared to the normal condition, RAD21 up-regulation increases probability of random collisions between RAD21 and loader, resulting in the assembly of more cohesin-loader complex and thus a decrease in the amount of free cohesin. Then loaded cohesin complex extrudes chromatin progressively, expanding TADs and even chromosome territories