Fig. 6

Associations between POE co-methylation module PCs and phenotypes. Only results for the phenotypes with at least one significant result are shown. The colors of the cells indicate the beta coefficient of the association. “*”: replicated associations (after Bonferroni correction). The three panels display the results for three different types of phenotypes separately, as the PCs sets used in the association tests were slightly different across phenotypes. This is because different covariates were used in pre-corrections for methylation levels when generating the module PCs (e.g., to test for the association with smoking status, the smoking variables should not be pre-corrected in methylation levels. The same applies to the aging phenotypes for which age was not pre-corrected). Left: phenotypes except for aging phenotypes and smoking status; middle: smoking status; right: aging phenotypes