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Fig. 8 | Genome Biology

Fig. 8

From: Caloric restriction remodels the hepatic chromatin landscape and bile acid metabolism by modulating the gut microbiota

Fig. 8

CR-induced microbiota shapes the hepatic epigenome coordinating altered Cyp8b1 responsible for bile acid metabolism. Short-term CR remodeled the hepatic enhancer landscape at genomic loci that were enriched for binding sites for signal-responsive transcription factors including HNF4α. Transferring CR gut microbiota into mice fed with an obesogenic diet recapitulated the features of CR-related bile acid metabolism along with attenuated fatty liver

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Genome Biology

ISSN: 1474-760X

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