Fig. 5

Feature ablation and attribution identify the contribution of epigenomic marks to 3D structure. A Correlation by distance for feature ablation experiments. Left to right: Pearson correlation for training chromosomes, Pearson correlation for test chromosomes. Spearman correlation for training chromosomes, Spearman correlation for test chromosomes. Blue track for model performance using all 5 epigenomic input tracks; green for training with an additional track SMC3; pink for model trained without CTCF; yellow for without DNaseI, dark red for only CTCF and H3K27ac tracks, and gray for model trained with only DNaseI and CTCF. B Feature attribution for bin (chr17:57,140,000–57,750,000) with Epiphany with Bi-LSTM layer (left) vs. modified Epiphany with convolution layer (right)