Fig. 3

Distribution of metabolic modules in genomes reconstructed from healthy individuals and individuals with IBD. The boxplots in A show the metabolic module completion values for (1) high and (2) low metabolic independence donor genomes identified in this study (blue and yellow), (3) genomes from healthy individuals (green), and (4) genomes from individuals with pouchitis (red) and Crohn’s disease (orange). Each dot in a given box-plot represents one of 33 metabolic modules that were enriched in HMI FMT donor populations and the y-axis indicates its estimated completion. The leftmost panel in A represents group averages and red whiskers indicate the median. The rightmost panel in A shows the distribution of metabolic modules for individuals within each group. In B the completion values for 10 of the 33 pathways are demonstrated as ridge-line plots. Each plot represents a single metabolic module where each layer corresponds to an individual, and the shape of the layer represents the completion of a given metabolic module across all genomes reconstructed from that individual. A high-resolution version of this figure is also available at https://doi.org/10.6084/m9.figshare.15138720 [26]