DREAMS: deep read-level error model for sequencing data applied to low-frequency variant calling and circulating tumor DNA detection

Table 3 Mutation calling performance (true-positive mutations and validation alterations)

	Full alteration catalog^a		Catalog alterations with signal^b
	Sensitivity	Specificity	Sensitivity	Specificity	F1	G-mean
DREAMS-vc	0.398	0.997	0.864	0.946	0.448	0.904
Shearwater	0.351	0.995	0.761	0.920	0.323	0.837
Mutect2	0.309	0.997	0.670	0.952	0.388	0.799

^aWhole catalog consisting of n = 191 true-positive mutations, and n = 43,500 validation alterations
^bCatalog of positions with signal consisting of n = 88 true positive mutations, and n = 1920 validation alterations

ISSN: 1474-760X