DREAMS: deep read-level error model for sequencing data applied to low-frequency variant calling and circulating tumor DNA detection

Table 2 Mutation calling performance (true-positive mutations and cross-patient negative calls)

	Full alteration catalog^a		Catalog alterations with signal^b
	Sensitivity	Specificity	Sensitivity	Specificity	F1	G-mean
DREAMS-vc	0.387	0.997	0.841	0.955	0.479	0.896
Shearwater	0.325	0.998	0.705	0.963	0.461	0.824
Mutect2	0.309	0.997	0.670	0.948	0.376	0.797

^aFull alteration catalog consisting of n = 191 true-positive mutations, and n = 12,900 potential cross-patient negative calls
^bCatalog of alterations with signal consisting of n = 88 true positive mutations, and n = 1330 potential cross-patient negative calls

ISSN: 1474-760X